Dynamic and equilibrium swelling behaviour of pH-sensitive hydrogels containing 2-hydroxyethyl methacrylate

Biomaterials. 1990 Nov;11(9):635-44. doi: 10.1016/0142-9612(90)90021-h.

Abstract

The equilibrium and dynamic swelling behaviour of hydrogels containing methacrylic acid or various acrylamides was studied as a function of copolymer composition. In all cases, the comonomer was 2-hydroxyethyl methacrylate, methyl methacrylate or N-vinyl-2-pyrrolidone. It is shown that pH-sensitive behaviour with a wide range of swelling ratios could be obtained using a range of compositional changes. The dynamic swelling behaviour was a function of the acidity of the buffered solution.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Buffers
  • Colloids / chemistry
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Hydrogen-Ion Concentration
  • Methacrylates / chemistry*
  • Methylmethacrylate
  • Methylmethacrylates / chemistry
  • Molecular Weight
  • Polyethylene Glycols / chemistry*
  • Pyrrolidinones / chemistry

Substances

  • Buffers
  • Colloids
  • Methacrylates
  • Methylmethacrylates
  • Pyrrolidinones
  • Methylmethacrylate
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Polyethylene Glycols
  • hydroxyethyl methacrylate
  • N-vinyl-2-pyrrolidinone