Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

S Sonnino; L Cantu; M Corti; D Acquotti; G Kirschner; G Tettamanti

doi:10.1016/0009-3084(90)90087-8

Aggregation properties of semisynthetic GM1 ganglioside (II3Neu5AcGgOse4Cer) containing an acetyl group as acyl moiety

Chem Phys Lipids. 1990 Nov;56(1):49-57. doi: 10.1016/0009-3084(90)90087-8.

Authors

S Sonnino¹, L Cantu, M Corti, D Acquotti, G Kirschner, G Tettamanti

Affiliation

¹ Department of Medical Chemistry and Biochemistry, Medical School, University of Milan, Italy.

PMID: 2091836
DOI: 10.1016/0009-3084(90)90087-8

Abstract

The aggregative properties of GM1 ganglioside containing an acetyl group as acyl moiety [GM1(acetyl)] in aqueous solution have been studied by static and dynamic light scattering measurements and surface tension experiments. GM1 (acetyl) spontaneously aggregates as small micelles showing a hydrodynamic radius and molecular weight of 34 A and 102 kDa, respectively, down to a concentration of 2.0 x 10(-5) M.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylation
Carbohydrate Sequence
Chemical Phenomena
Chemistry, Physical
Chromatography, High Pressure Liquid
G(M1) Ganglioside / chemistry*
Light
Macromolecular Substances
Magnetic Resonance Spectroscopy
Micelles
Molecular Sequence Data
Molecular Weight
Scattering, Radiation
Surface Tension

Substances

Macromolecular Substances
Micelles
G(M1) Ganglioside