Abstract
PIWI-interacting RNAs (piRNAs) play an important role in silencing transposons within the germline; how they are generated and how they exert their silencing function is not well understood. Here Phil Zamore highlights recent work from the Brennecke lab that provides new insight into the factors involved in these small RNA biogenesis pathways.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Active Transport, Cell Nucleus / physiology
-
Animals
-
Argonaute Proteins
-
Drosophila
-
Drosophila Proteins / metabolism
-
Endoribonucleases / metabolism
-
Female
-
Models, Biological
-
Ovarian Follicle / metabolism*
-
RNA Interference / physiology*
-
RNA, Small Interfering / biosynthesis*
-
RNA, Small Interfering / metabolism
-
RNA-Induced Silencing Complex / metabolism
Substances
-
Argonaute Proteins
-
Drosophila Proteins
-
RNA, Small Interfering
-
RNA-Induced Silencing Complex
-
piwi protein, Drosophila
-
Endoribonucleases
-
Zuc protein, Drosophila