Abstract
The detection of Enterobacteriaceae carrying the carbapenemase KPC has been problematic. Thirty isolates of KPC-possessing Escherichia coli were gathered from hospitals in New York City and Connecticut. The imipenem, meropenem, doripenem, and ertapenem MIC50 values were 4, 2, 1, and 4 μg/ml, respectively. Over half of the isolates belonged to a single ribotype. Using an ertapenem breakpoint of 0.25 μg/ml would efficiently detect these isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / biosynthesis*
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Bacterial Proteins / genetics
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Bacterial Typing Techniques
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Connecticut / epidemiology
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Escherichia coli / classification
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Escherichia coli / enzymology*
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Escherichia coli / genetics
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Escherichia coli / isolation & purification*
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Escherichia coli Infections / epidemiology*
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Escherichia coli Infections / microbiology*
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Genotype
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Humans
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Microbial Sensitivity Tests
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Molecular Epidemiology
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New York City / epidemiology
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Ribotyping
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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beta-Lactams
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beta-Lactamases
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carbapenemase