Abstract
Time to detection of Mycobacterium tuberculosis in broth culture was examined for utility as a treatment efficacy end point. Of 146 patients in a phase IIB trial, a decreased mean time to detection was found in 5 with treatment failure. Time to detection in an analysis-of-covariance model was associated with lung cavities, less intensive treatment, and differences in the bactericidal effects of treatment regimens.
Publication types
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Evaluation Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Antitubercular Agents / therapeutic use
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Aza Compounds / therapeutic use
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Bacteriological Techniques / methods*
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Clinical Trials as Topic
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Drug Monitoring / methods*
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Ethambutol / therapeutic use
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Female
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Fluoroquinolones
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Humans
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Male
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Middle Aged
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Moxifloxacin
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Mycobacterium tuberculosis / isolation & purification*
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Quinolines / therapeutic use
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Time Factors
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Tuberculosis / diagnosis*
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Tuberculosis / drug therapy*
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Tuberculosis / microbiology
Substances
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Antitubercular Agents
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Aza Compounds
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Fluoroquinolones
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Quinolines
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Ethambutol
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Moxifloxacin