Tic disorder (TD) is a chronic neuropsychiatric disorder with childhood onset. Previous research has demonstrated that genetic factors play an important role in the pathogenesis of TD, and TD is a complex disease affected by multiple genes. Many susceptibility genes have been identified and the relationship between these genes and the etiology of TD was investigated in the past few years. These researches have yielded large valuable information as well as provided a reference for understanding the pathogenesis and further research of this disease. In this paper we reviewed the recent progress in the study on the susceptibility gene mapping of TD.