In-silico study of 4-methylsulfinyl-3-butenyl isothiocyanate binding to tubulin induces A549 cells apoptosis

Yao Xue Xue Bao. 2010 Jul;45(7):934-9.

Authors

Nan Wang¹, Tao Qu, Lian-qing Shen, Kui-wu Wang, Xiang-yang Wang, Ai-li Wu, Yue Tang

Affiliation

¹ College of Food Science and Biotechnology Engineering, Zhejiang Gongshang University, Hangzhou 310035, China.

PMID: 20931795

No abstract available

MeSH terms

Anticarcinogenic Agents / administration & dosage
Anticarcinogenic Agents / isolation & purification
Anticarcinogenic Agents / pharmacology*
Apoptosis / drug effects*
Carcinoma, Non-Small-Cell Lung / pathology*
Cell Line, Tumor
Cell Proliferation / drug effects
Dose-Response Relationship, Drug
Humans
Isothiocyanates / administration & dosage
Isothiocyanates / isolation & purification
Isothiocyanates / pharmacology*
Lung Neoplasms / pathology*
Plants, Medicinal / chemistry
Protein Binding
Raphanus / chemistry
Tubulin* / chemistry
Tubulin* / metabolism

Substances

4-methylsulfinyl-3-butenyl isothiocyanate
Anticarcinogenic Agents
Isothiocyanates
Tubulin