Abstract
Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g/day), subjects consumed a single oral bolus of the appropriate [1-(13)C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was similar for 9c-18:1 and 10t,12c (P = 0.66), but significantly higher for 9c,11t (P < 0.01).
Publication types
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Disease Progression
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Double-Blind Method
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Female
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Health*
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Humans
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Isomerism
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Linoleic Acids, Conjugated / administration & dosage
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Linoleic Acids, Conjugated / chemistry
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Linoleic Acids, Conjugated / metabolism
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Linoleic Acids, Conjugated / pharmacokinetics
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Lipid Metabolism / drug effects
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Male
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Middle Aged
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Oleic Acid / administration & dosage
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Oleic Acid / chemistry
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Oleic Acid / metabolism*
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Oleic Acid / pharmacokinetics
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Overweight / metabolism*
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Oxidation-Reduction
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Placebos
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Postprandial Period*
Substances
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Linoleic Acids, Conjugated
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Placebos
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Oleic Acid