Abstract
We present a pediatric case of recurrent optic neuritis, celiac disease, partial IgA and IgG3 deficiency in the context of anti-aquaporin-4 auto-immunity and familial IgA deficiency with celiac disease. Treatment with tacrolimus was successful in preventing disease relapses. This case stresses the relevance of central nervous system anti-aquaporin-4 auto-immunity in a broader context of immune dysregulation and neuro-immunology.
Copyright © 2010 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Autoantibodies / biosynthesis*
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Autoantibodies / blood
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Celiac Disease / complications
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Celiac Disease / drug therapy
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Celiac Disease / immunology*
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Child
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Dysgammaglobulinemia / complications
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Dysgammaglobulinemia / drug therapy
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Dysgammaglobulinemia / immunology*
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Female
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Humans
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Immunoglobulin G / biosynthesis*
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Immunoglobulin G / blood
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Immunosuppressive Agents / administration & dosage
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Neuromyelitis Optica / complications
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Neuromyelitis Optica / drug therapy
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Neuromyelitis Optica / immunology*
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Optic Neuritis / complications
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Optic Neuritis / drug therapy
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Optic Neuritis / immunology*
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Tacrolimus / administration & dosage*
Substances
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Autoantibodies
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Immunoglobulin G
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Immunosuppressive Agents
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Tacrolimus