Abstract
We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Cell Line, Tumor
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Coated Materials, Biocompatible / chemical synthesis*
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Contrast Media / chemical synthesis
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Dextrans* / chemical synthesis
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Glioblastoma / pathology*
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Humans
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Magnetic Resonance Imaging / methods*
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Magnetite Nanoparticles*
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Mice
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Nanostructures / chemistry*
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Polyethylene Glycols / chemistry*
Substances
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Coated Materials, Biocompatible
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Contrast Media
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Dextrans
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Magnetite Nanoparticles
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ferumoxtran-10
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Polyethylene Glycols