Influence of extraction protocol on physical properties of parvovirus B19 DNA

J Clin Microbiol. 2010 Dec;48(12):4595-7. doi: 10.1128/JCM.00571-10. Epub 2010 Oct 13.

Abstract

While establishing a quantification standard for parvovirus B19 diagnostics, we extracted viral DNA from a high-titered human plasma by using three commercial kits. Despite similar viral DNA yields being obtained, striking differences in electrophoretic mobilities of the extracted nucleic acids were observed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Viral / genetics*
  • DNA, Viral / isolation & purification*
  • Electrophoresis
  • Humans
  • Parvovirus B19, Human / genetics*
  • Plasma / virology
  • Reagent Kits, Diagnostic
  • Specimen Handling / methods*
  • Virology / methods*

Substances

  • DNA, Viral
  • Reagent Kits, Diagnostic