Abstract
The palladium-catalyzed coupling of an aziridinylzinc chloride intermediate with alkenyl and aryl halides has been demonstrated. The method provides products with retention of aziridine stereochemistry. The utility of the coupling procedure is illustrated in the synthesis of structures related to l-furanomycin.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Alkenes / chemistry*
-
Amino Acids / chemical synthesis*
-
Amino Acids / chemistry
-
Aziridines / chemistry*
-
Catalysis
-
Chlorides / chemistry
-
Combinatorial Chemistry Techniques
-
Hydrocarbons, Halogenated / chemistry*
-
Molecular Structure
-
Palladium / chemistry*
-
Stereoisomerism
-
Zinc Compounds / chemistry
Substances
-
Alkenes
-
Amino Acids
-
Aziridines
-
Chlorides
-
Hydrocarbons, Halogenated
-
Zinc Compounds
-
furanomycin
-
Palladium
-
zinc chloride