The Myc connection: ES cells and cancer

Michael E Rothenberg; Michael F Clarke; Maximilian Diehn

doi:10.1016/j.cell.2010.09.046

The Myc connection: ES cells and cancer

Cell. 2010 Oct 15;143(2):184-6. doi: 10.1016/j.cell.2010.09.046.

Authors

Michael E Rothenberg¹, Michael F Clarke, Maximilian Diehn

Affiliation

¹ Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

PMID: 20946977
DOI: 10.1016/j.cell.2010.09.046

Abstract

Gene profiling experiments have revealed similarities between cancer and embryonic stem (ES) cells. Kim et al. (2010) dissect the gene expression signature of ES cells into three functional modules and find that the Myc module, including genes targeted by Myc-interacting proteins, accounts for most of the similarity between ES and cancer cells.

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