Abstract
A 5-month-old female Great Dane puppy was treated for hematochezia, tenesmus, and rectal prolapse by resection of a 10-cm-long segment of colon and rectum. Grossly, the colorectal segment had diffuse mucosal and submucosal thickening with multiple polypoid nodules. The histologic diagnosis was colorectal hamartomatous polyps with ganglioneuromatosis. Duplication of PTEN was detected by quantitative multiplex polymerase chain reaction testing. The presence of 2 hamartomatous colorectal lesions with PTEN mutation is similar to human Cowden syndrome.
MeSH terms
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Animals
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Colorectal Neoplasms / genetics
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / surgery
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Colorectal Neoplasms / veterinary*
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DNA, Neoplasm / chemistry
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DNA, Neoplasm / genetics
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Dog Diseases / genetics
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Dog Diseases / pathology*
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Dog Diseases / surgery
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Dogs
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Female
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Ganglioneuroma / genetics
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Ganglioneuroma / pathology
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Ganglioneuroma / surgery
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Ganglioneuroma / veterinary*
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Hamartoma / genetics
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Hamartoma / pathology
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Hamartoma / surgery
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Hamartoma / veterinary*
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Immunohistochemistry / veterinary
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Intestinal Polyps / genetics
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Intestinal Polyps / pathology
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Intestinal Polyps / surgery
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Intestinal Polyps / veterinary*
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PTEN Phosphohydrolase / genetics
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PTEN Phosphohydrolase / metabolism*
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Polymerase Chain Reaction / veterinary
Substances
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DNA, Neoplasm
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PTEN Phosphohydrolase