Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates

A Andreani; M Rambaldi; A Locatelli; F Andreani; P Aresca; R Bossa; I Galatulas

Potential antitumor agents XVII (1). Cytotoxic agents from indole derivatives and their intermediates

Acta Pharm Nord. 1990;2(6):407-14.

Authors

A Andreani¹, M Rambaldi, A Locatelli, F Andreani, P Aresca, R Bossa, I Galatulas

Affiliation

¹ Dipartimento di Scienze Farmaceutiche, University of Bologna, Italy.

PMID: 2095799

Abstract

New indole derivatives and their intermediates were tested as cytotoxic agents on a culture of P388 leukemia cells. The aldehyde 2a was more active than the thiosemicarbazones 3a, b and the nitrosourea 14. The chloroacetyl derivatives 10, 11 were the most potent cytotoxic agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Indoles / chemical synthesis*
Indoles / pharmacology
Leukemia P388 / drug therapy
Tumor Cells, Cultured / drug effects

Substances

Antineoplastic Agents
Indoles