Abstract
Early treatment of meningococcal meningitis is mandatory but may negate the cerebrospinal fluid culture. Etiological diagnosis then mainly relies on PCR. Here, we report a case of false-negative results for real-time PCR for a Neisseria meningitidis serogroup B isolate with a polymorphism in the ctrA gene.
MeSH terms
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Bacterial Proteins / genetics
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Bacteriological Techniques / methods*
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Child, Preschool
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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False Negative Reactions*
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Humans
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Male
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Meningococcal Infections / diagnosis
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Meningococcal Infections / microbiology*
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Molecular Sequence Data
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Neisseria meningitidis / genetics*
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Neisseria meningitidis / isolation & purification
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Polymerase Chain Reaction / methods*
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Polymorphism, Genetic*
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Sequence Analysis, DNA
Substances
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Bacterial Proteins
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DNA, Bacterial