[Alteration of calcium signaling as one of the mechanisms of Alzheimer's disease and diabetic polyneuropathy]

O P Kostiuk; T Iu Korol'; S V Korol'; S V Romanenko; V O Pinchenko; P H Kostiuk

[Alteration of calcium signaling as one of the mechanisms of Alzheimer's disease and diabetic polyneuropathy]

Fiziol Zh (1994). 2010;56(4):130-8.

[Article in Ukrainian]

Authors

O P Kostiuk, T Iu Korol', S V Korol', S V Romanenko, V O Pinchenko, P H Kostiuk

PMID: 20968046

Abstract

This review is devoted to the action of amyloid-beta peptide on the functional activity of intracellular and plasmalemmal calcium-regulated structures in cultured hyppocampal neurons: mitochondria and voltage-gated calcium channels. A comparative analysis of relative changes of plasmalemmal structures in such neurodegenerative diseases as Alzheimer's illness and diabetic neuropathy has been made.

Publication types

English Abstract
Review

MeSH terms

Alzheimer Disease / etiology*
Alzheimer Disease / metabolism
Amyloid beta-Peptides / pharmacology
Animals
Calcium Channels / metabolism
Calcium Signaling* / physiology
Cell Membrane / drug effects
Cell Membrane / metabolism
Diabetic Neuropathies / etiology*
Diabetic Neuropathies / metabolism
Hippocampus / drug effects
Hippocampus / metabolism
Humans
Mitochondria / drug effects
Mitochondria / metabolism
Neurons / drug effects
Neurons / metabolism
Rats

Substances

Amyloid beta-Peptides
Calcium Channels