Abstract
The results of a theoretical investigation on the complex cascade reaction leading to the natural product rubicordifolin are reported. These computations analyze the discrete transformations that are required during the conversion of the vinyl naphthoquinone starting material into the natural product, including two pseudopericyclic cyclizations as well as a diastereoselective, hetero-Diels-Alder reaction.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Catalysis
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Cyclization
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Furans / chemical synthesis*
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Furans / chemistry
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Models, Molecular*
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Molecular Structure
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Naphthols / chemical synthesis*
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Naphthols / chemistry
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Plants, Medicinal / chemistry
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Pyrones / chemical synthesis*
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Pyrones / chemistry
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Rubia / chemistry
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Stereoisomerism
Substances
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Biological Products
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Furans
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Naphthols
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Pyrones
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furomollugin
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rubicordifolin