Primary malignant bone neoplasm: a case report of dedifferentiated chondrosarcoma in the rib and review of the literature

Chin J Cancer. 2010 Nov;29(11):964-8. doi: 10.5732/cjc.009.10390.

Abstract

Dedifferentiated chondrosarcoma (DDCS) is a rare but highly malignant primary bone neoplasm, which is resistant to radiotherapy and chemotherapy. There remains uncertainly as to the best treatment of this disease and how to improve its prognosis. In this paper we reported a case of DDCS and reviewed the related literatures in order to provide references to throw a light on the histogenesis, diagnosis and therapy of this disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Neoplasms / diagnostic imaging*
  • Bone Neoplasms / drug therapy
  • Bone Neoplasms / pathology
  • Chondrosarcoma / diagnostic imaging*
  • Chondrosarcoma / drug therapy
  • Chondrosarcoma / pathology
  • Cisplatin / administration & dosage
  • Doxorubicin / administration & dosage
  • Doxorubicin / analogs & derivatives
  • Follow-Up Studies
  • Hemangioendothelioma / diagnostic imaging
  • Hemangioendothelioma / drug therapy
  • Hemangioendothelioma / secondary*
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary*
  • Male
  • Methotrexate / administration & dosage
  • Multimodal Imaging
  • Positron-Emission Tomography
  • Ribs*
  • Tomography, X-Ray Computed

Substances

  • Doxorubicin
  • pirarubicin
  • Cisplatin
  • Methotrexate