Abstract
There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.
© 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / immunology*
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Animals
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CARD Signaling Adaptor Proteins
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Cytokines / metabolism
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Female
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Immunity, Innate / genetics*
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Lectins, C-Type
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Membrane Proteins / deficiency
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Membrane Proteins / immunology*
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Mice
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Mice, Knockout
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Mycobacterium tuberculosis / immunology*
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Nerve Tissue Proteins / deficiency
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Nerve Tissue Proteins / immunology*
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Nuclear Proteins / immunology*
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Transcription Factors
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Tuberculosis, Pulmonary / immunology*
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Tuberculosis, Pulmonary / pathology
Substances
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Adaptor Proteins, Signal Transducing
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CARD Signaling Adaptor Proteins
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Card9 protein, mouse
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Cytokines
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Lectins, C-Type
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Membrane Proteins
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Nerve Tissue Proteins
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Nuclear Proteins
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Skiip protein, mouse
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Transcription Factors
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dectin 1