Abstract
Somitogenesis is a term that encompasses somite formation, patterning and differentiation and it is a process that is fundamental to the formation of the axial skeleton in vertebrates. Notch signalling is a mechanism used to specify cell fate in many different contexts, with signalling occurring between cells in contact. Notch signalling is fundamental to the formation and patterning of somites and importantly a ligand of Notch, is mutated in the abnormal vertebral segmentation syndrome spondylocostal dysostosis. Here we discuss what is known about the expression and function of this ligand, Delta-like-3, during somitogenesis and vertebral column formation in mouse and humans.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Abnormalities, Multiple / genetics
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Animals
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Body Patterning
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Gene Expression Regulation, Developmental
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Glycosylation
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Heart Defects, Congenital / genetics
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Hernia, Diaphragmatic / genetics
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Humans
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Intracellular Signaling Peptides and Proteins / genetics
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Intracellular Signaling Peptides and Proteins / metabolism*
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Ligands
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mice
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Mutation
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Phylogeny
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Receptors, Notch / metabolism
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Signal Transduction
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Somites / embryology*
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Somites / metabolism*
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Spine / embryology*
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Spine / metabolism*
Substances
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DLL3 protein, human
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Dll3 protein, mouse
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Intracellular Signaling Peptides and Proteins
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Ligands
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Membrane Proteins
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Receptors, Notch