Background: To investigate the relationship between histological classification of lung cancer and protein tyrosine phosphatase.
Methods: The expression of protein tyrosine phosphatase in bronchial epithelia from 34 patients with benign pulmonary lesions and 121 patients with primary pulmonary carcinoma was examined by immunohistochemical staining method.
Results: The positive rate of protein tyrosine phosphatase expression was 95.03%±2.10% in 34 patients with benign pulmonary lesions, 43.59%±14.41% in 121 patients with primary pulmonary carcinoma; 47.57%±16.26% in 46 patients with adenocarcinoma, 40.59%±14.04% in 48 patients with squamous cell carcinoma, 42.13%±9.84% in 27 patients with adenosquamous carcinoma; 31.63%±10.34% in 21 patients with poor differentiated squamous cell carcinoma, 41.39%±9.35% in 18 patients with intermediate differentiated squamous cell carcinoma, 59.90%±8.61% in 9 patients with well differentiated squamous cell carcinoma; 34.14%±12.53% in 16 patients with poor differentiated adenocarcinoma, 52.10%±12.19% in 26 patients with intermediate differentiated adenocarcinoma, and 63.05%±15.84% in 4 patients with well differentiated adenocarcinoma. A significant difference of protein tyrosine phosphatase positive expression was observed between benign pulmonary lesions and primary pulmonary carcinomas, and between poor differentiated primary pulmonary carcinomas and well differentiated primary pulmonary carcinomas (P<0.01 or P<0.05).
Conclusions: Detection of protein tyrosine phosphatase may be helpful to differentiate pulmonary lesions from lung cancer and be regarded as one of the indices in predicting the prognosis of patients with primary pulmonary carcinomas.