[Radionuclide therapy for neuroendocrine tumours]

Ugeskr Laeger. 2010 Oct 25;172(43):2950-3.
[Article in Danish]

Abstract

Peptide receptor radionuclide therapy using somatostatin analogues labelled with beta-emitting isotopes can be given to patients with metastasized or inoperable neuroendocrine tumours provided these have increased uptake on octreotide scintigraphy. This is a brief review of the treatment principle, indications and contraindications and practices with (177)Lu-DOTATATE treatment used at Rigshospitalet. Side effects are generally mild and reversible. Severe long-term side effects are rare. The majority of patients will experience increased quality of life and partial tumour reduction or stabilization for a period of time. However, up to 20% will experience no treatment effect.

MeSH terms

  • Contraindications
  • Gastrointestinal Neoplasms / diagnostic imaging
  • Gastrointestinal Neoplasms / drug therapy
  • Gastrointestinal Neoplasms / radiotherapy*
  • Humans
  • Neuroendocrine Tumors / diagnostic imaging
  • Neuroendocrine Tumors / drug therapy
  • Neuroendocrine Tumors / radiotherapy*
  • Octreotide / adverse effects
  • Octreotide / analogs & derivatives*
  • Octreotide / therapeutic use
  • Organometallic Compounds / adverse effects
  • Organometallic Compounds / therapeutic use*
  • Radionuclide Imaging
  • Treatment Outcome

Substances

  • Organometallic Compounds
  • lutetium Lu 177 dotatate
  • Octreotide