Abstract
Three Acinetobacter baumannii isolates that possess OXA-40 group carbapenemase genes were identified. They belonged to novel sequence types (ST122, ST123, and ST124) and harbored bla(OXA-160), bla(OXA-72), and bla(OXA-40), respectively. OXA-160 is a novel variant of OXA-40 with a P227S substitution. An isogenic Escherichia coli clone producing OXA-160 was more susceptible to carbapenems than a clone producing OXA-40. The genetic environment of bla(OXA-160) and bla(OXA-40) beyond the putative XerC/XerD recombination sites was distinct from the scaffold reported previously.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / enzymology*
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Aged
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Aminoglycosides / pharmacology
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Anti-Bacterial Agents / pharmacology
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism*
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Carbapenems / pharmacology
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Electrophoresis, Gel, Pulsed-Field
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Female
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Fluoroquinolones / pharmacology
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Humans
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Imipenem / pharmacology
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Pennsylvania
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beta-Lactamases / genetics
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beta-Lactamases / metabolism*
Substances
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Aminoglycosides
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Anti-Bacterial Agents
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Bacterial Proteins
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Carbapenems
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Fluoroquinolones
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Imipenem
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beta-Lactamases
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carbapenemase
Associated data
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GENBANK/GU199038
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GENBANK/GU199039
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GENBANK/GU199040