The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2

Nicola Philpott; Thomas Bakken; Christopher Pennell; Liwei Chen; Jie Wu; Mark Cannon

doi:10.1128/JVI.01362-10

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2

J Virol. 2011 Jan;85(2):1140-4. doi: 10.1128/JVI.01362-10. Epub 2010 Nov 3.

Authors

Nicola Philpott¹, Thomas Bakken, Christopher Pennell, Liwei Chen, Jie Wu, Mark Cannon

Affiliation

¹ Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

The Kaposi's sarcoma-associated herpesvirus (KSHV) G protein-coupled receptor (vGPCR) is a constitutively active, highly angiogenic homologue of the interleukin-8 (IL-8) receptors that signals in part via the cytoplasmic protein tyrosine phosphatase Shp2. We show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Motifs
Cell Line
Herpesvirus 8, Human / pathogenicity*
Host-Pathogen Interactions*
Humans
Models, Molecular
Protein Binding
Protein Tyrosine Phosphatase, Non-Receptor Type 11 / metabolism*
Receptors, Chemokine / metabolism*
Surface Plasmon Resonance

Substances

G protein-coupled receptor, Human herpesvirus 8
Receptors, Chemokine
Protein Tyrosine Phosphatase, Non-Receptor Type 11