In(III)-catalyzed tandem reaction of chromone-derived Morita-Baylis-Hillman alcohols with amines

Org Biomol Chem. 2011 Jan 7;9(1):253-6. doi: 10.1039/c0ob00604a. Epub 2010 Nov 3.

Abstract

The reaction of chromone-derived cyclic Morita-Baylis-Hillman alcohols with amines catalyzed by In(OTf)(3) in a one pot process was developed for the convenient and efficient synthesis of 2-substituted-3-aminomethylenechromans. The tandem allylic amination/chromen ring-opening/Michael cyclization reactions were involved in this protocol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Amines / chemistry*
  • Catalysis
  • Chromones / chemistry*
  • Indium / chemistry*
  • Models, Molecular
  • Molecular Structure

Substances

  • Alcohols
  • Amines
  • Chromones
  • Indium