Nanostructure-initiator mass spectrometry metabolite analysis and imaging

Matthew P Greving; Gary J Patti; Gary Siuzdak

doi:10.1021/ac101565f

Nanostructure-initiator mass spectrometry metabolite analysis and imaging

Anal Chem. 2011 Jan 1;83(1):2-7. doi: 10.1021/ac101565f. Epub 2010 Nov 4.

Authors

Matthew P Greving¹, Gary J Patti, Gary Siuzdak

Affiliation

¹ Center for Metabolomics and Mass Spectrometry, Department of Chemistry, The Scripps Research Institute.

Abstract

Nanostructure-Initiator Mass Spectrometry (NIMS) is a matrix-free desorption/ionization approach that is particularly well-suited for unbiased (untargeted) metabolomics. An overview of the NIMS technology and its application in the detection of biofluid and tissue metabolites are presented. (To listen to a podcast about this feature, please go to the Analytical Chemistry multimedia page at pubs.acs.org/page/ancham/audio/index.html .).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Clinical Chemistry Tests
Mass Spectrometry / methods*
Metabolomics / methods*
Molecular Imaging / methods*
Nanostructures*

Abstract

Publication types

MeSH terms

Grants and funding