Abstract
The adherent layer that forms in human bone marrow suspension cultures contains fibroblast colonies which arise from colony-forming cells (CFU-F). We have demonstrated that recombinant interleukin-2 (r-IL2) inhibits growth of CFU-F by preventing their entry into S phase. This inhibition is not mediated by gamma-interferon, nor by T lymphocytes, and can be abrogated by anti-IL2 receptor antibody. r-IL2 may influence haematopoiesis by its effect on bone marrow CFU-F.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biological Factors / pharmacology
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Bone Marrow / drug effects*
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Bone Marrow Cells
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Cell Adhesion / drug effects
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Cell Division / drug effects
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Cells, Cultured / cytology
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Cells, Cultured / drug effects
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Colony-Forming Units Assay
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Cytokines
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Depression, Chemical
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Dose-Response Relationship, Drug
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Humans
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Interleukin-2 / pharmacology*
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Recombinant Proteins / pharmacology
Substances
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Biological Factors
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Cytokines
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Interleukin-2
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Recombinant Proteins