Abstract
Herein, we developed matrix metalloprotease (MMP) sensitive gold nanorods (MMP-AuNR) for cancer imaging and therapy. It was feasible to absorb NIR laser and convert into heat as well as visualize MMP activity. We showed the possibility of gold nanorods as a hyperthermal therapeutic agent and MMP sensitive imaging agent both in vitro and in vivo condition. The results suggested potential application of MMP-AuNR for simultaneous cancer diagnosis and therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carcinoma, Squamous Cell* / diagnosis
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Carcinoma, Squamous Cell* / therapy
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Cell Line, Tumor
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Diagnostic Imaging / methods*
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Enzyme Inhibitors / pharmacology
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Fluorescence
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Gold* / chemistry
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Gold* / therapeutic use
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Hot Temperature
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Laser Therapy / methods*
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Light
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Matrix Metalloproteinase Inhibitors
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Matrix Metalloproteinases / chemistry
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Matrix Metalloproteinases / metabolism*
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Mice
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Mice, Nude
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Microscopy, Electron, Transmission
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Nanotubes / chemistry
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Neoplasm Transplantation
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Phototherapy / methods*
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Skin Neoplasms* / diagnosis
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Skin Neoplasms* / therapy
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Spectrometry, Fluorescence
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Spectroscopy, Near-Infrared
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Temperature
Substances
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Enzyme Inhibitors
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Matrix Metalloproteinase Inhibitors
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Gold
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Matrix Metalloproteinases