Cooperative melting in caged dimers with only two DNA duplexes

J Am Chem Soc. 2010 Dec 8;132(48):17068-70. doi: 10.1021/ja107232x. Epub 2010 Nov 12.

Abstract

Small molecule-DNA hybrids with only two parallel DNA duplexes (rSMDH2) displayed sharper melting profiles compared to unmodified DNA duplexes, consistent with predictions from neighboring-duplex theory. Using adjusted thermodynamic parameters obtained from a coarse-grain dynamic simulation, the experimental data fit well to an analytical model.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • DNA / chemistry*
  • DNA / genetics
  • Dimerization*
  • Molecular Dynamics Simulation
  • Nucleic Acid Conformation
  • Nucleic Acid Denaturation
  • Phase Transition*
  • Transition Temperature

Substances

  • DNA