HLA polymorphisms in Italian children with autism spectrum disorders: results of a family based linkage study

J Neuroimmunol. 2011 Jan;230(1-2):135-42. doi: 10.1016/j.jneuroim.2010.10.019. Epub 2010 Nov 17.

Abstract

To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case-control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child Development Disorders, Pervasive / genetics*
  • Female
  • Genetic Linkage*
  • Genetic Predisposition to Disease / genetics*
  • HLA Antigens / genetics*
  • Haplotypes
  • Humans
  • Italy
  • Male
  • Microsatellite Repeats / genetics
  • Polymorphism, Single Nucleotide*

Substances

  • HLA Antigens