Magnetic resonance dynamic susceptibility-weighted contrast-enhanced perfusion imaging in the diagnosis of posterior fossa hemangioblastomas and pilocytic astrocytomas: initial results

J Comput Assist Tomogr. 2010 Nov-Dec;34(6):825-9. doi: 10.1097/RCT.0b013e3181ef77e2.

Abstract

Objective: The purpose of this study was to compare the dynamic susceptibility-weighted contrast-enhanced (DSC) magnetic resonance (MR) perfusion and MR imaging findings between hemangioblastomas and pilocytic astrocytoma (PA).

Methods: We retrospectively identified 6 patients with hemangioblastomas and 8 patients with PAs who underwent MR imaging before resection. Using fluid-attenuated inversion-recovery imaging, we graded peritumoral edema as absent, minimal, mild, moderate, or severe. In addition, 3 patients with hemangioblastomas and 4 patients with PAs underwent DSC-MR imaging before resection.

Results: We observed moderate to severe peritumoral edema in 6 patients with hemangioblastomas and none or minimal peritumoral edema in 8 patients with PAs. The mean relative cerebral blood volume was 7.7 (SD, 1.0) in patients with hemangioblastomas and 1.8 (SD, 1.8) in patients with PAs.

Conclusions: Our preliminary findings demonstrate significantly higher DSC-MR imaging relative cerebral blood volumes in patients with hemangioblastomas when compared with patients with PAs. In addition, moderate to severe peritumoral edema was associated with hemangioblastomas.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Astrocytoma / diagnosis*
  • Astrocytoma / pathology
  • Child
  • Child, Preschool
  • Contrast Media
  • Edema / diagnosis
  • Female
  • Gadolinium DTPA
  • Hemangioblastoma / diagnosis*
  • Hemangioblastoma / pathology
  • Humans
  • Image Interpretation, Computer-Assisted
  • Infratentorial Neoplasms / diagnosis*
  • Infratentorial Neoplasms / pathology
  • Magnetic Resonance Imaging / methods*
  • Male
  • Middle Aged
  • Retrospective Studies

Substances

  • Contrast Media
  • Gadolinium DTPA