Antibody to blood group glycosyltransferases in a patient transplanted with an ABO incompatible bone marrow

Exp Clin Immunogenet. 1990;7(2):85-90.

Abstract

In the plasma of a blood group B recipient who was transplanted with a blood group O bone marrow, we investigated an antibody to inhibit the activities of blood group A- and B-glycosyltransferases. When B lymphocytes from the patient were transformed with Epstein-Barr virus, a few clones producing antibodies to B-transferase were obtained.

Publication types

  • Case Reports

MeSH terms

  • ABO Blood-Group System / immunology*
  • Adult
  • B-Lymphocytes / immunology
  • Blood Group Incompatibility / immunology*
  • Bone Marrow Transplantation / immunology*
  • Clone Cells / immunology
  • Cross Reactions
  • Galactosyltransferases / immunology*
  • Humans
  • Immunoglobulin G / biosynthesis
  • Immunoglobulin G / immunology
  • Immunoglobulin M / biosynthesis
  • Immunoglobulin M / immunology
  • Isoantibodies / immunology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / surgery
  • Male
  • N-Acetylgalactosaminyltransferases*
  • Transplantation, Homologous

Substances

  • ABO Blood-Group System
  • Immunoglobulin G
  • Immunoglobulin M
  • Isoantibodies
  • Galactosyltransferases
  • N-Acetylgalactosaminyltransferases
  • UDPgalactosamine-galactose acetylgalactosaminyltransferase
  • blood-group-substance alpha-D-galactosyltransferase