Abstract
Naturally occurring antrocamphin A (1) is a potent anti-inflammatory compound from the edible fungus Antrodia camphorata (Taiwanofungus camphoratus), whose wild fruiting body is used as a valuable folk medicine in Taiwan. This study is the first total synthesis of antrocamphin A (1) and its analogs. Their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemical synthesis*
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Alkynes / pharmacology
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Anisoles / chemical synthesis*
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Anisoles / pharmacology
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Anti-Inflammatory Agents / chemical synthesis*
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Anti-Inflammatory Agents / pharmacology
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Anticoagulants / chemical synthesis*
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Anticoagulants / pharmacology
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Humans
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Molecular Structure
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Neutrophils / drug effects
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Structure-Activity Relationship
Substances
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Alkynes
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Anisoles
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Anti-Inflammatory Agents
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Anticoagulants
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antrocamphin A