Abstract
The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Autoantigens
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Autoimmune Diseases / immunology
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Autoimmunity*
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CD4 Antigens / analysis
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Forkhead Transcription Factors / analysis
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Humans
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Immunomodulation*
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Inflammation
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Interleukin-2 Receptor alpha Subunit / immunology
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Mice
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Self Tolerance*
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
Substances
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Autoantigens
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CD4 Antigens
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FOXP3 protein, human
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Forkhead Transcription Factors
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Interleukin-2 Receptor alpha Subunit