Abstract
Psychotic symptoms occur in approximately 40% of subjects with Alzheimer disease (AD with psychosis; AD + P) and identify a subgroup with more rapid cognitive decline. We evaluated in 867 AD subjects the association of AD + P with genes which may modify the pathological process via effects on the accumulation of amyloid beta (Aβ) protein and/or hyperphosphorylated microtubule-associated protein tau (MAPT): amyloid precursor protein (APP), beta-site amyloid precursor protein cleaving enzyme (BACE1), sortilin-related receptor (SORL1), and MAPT. Each gene was thoroughly interrogated with tag single-nucleotide polymorphisms (SNPs), and gene-based tests were used to enhance power. We found no association of these genes with AD + P.
Copyright © 2011 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / complications
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Alzheimer Disease / genetics
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Amyloid Precursor Protein Secretases / genetics*
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Amyloid beta-Peptides / metabolism
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Amyloid beta-Protein Precursor / genetics*
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Aspartic Acid Endopeptidases / genetics*
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Female
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Genome-Wide Association Study / methods
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Humans
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LDL-Receptor Related Proteins / genetics*
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Male
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Membrane Transport Proteins / genetics*
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Nerve Degeneration / complications
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Nerve Degeneration / genetics
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Polymorphism, Single Nucleotide / genetics*
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Psychotic Disorders / etiology
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Psychotic Disorders / genetics*
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tau Proteins / genetics*
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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LDL-Receptor Related Proteins
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MAPT protein, human
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Membrane Transport Proteins
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SORL1 protein, human
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tau Proteins
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Amyloid Precursor Protein Secretases
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Aspartic Acid Endopeptidases
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BACE1 protein, human