Abstract
Introduction:
Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF.
Methods:
We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF.
Results:
Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74).
Conclusions:
This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.
Copyright © 2010 Elsevier Inc. All rights reserved.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Area Under Curve
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Baltimore
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Biomarkers / blood
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Biomarkers / urine
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Delayed Graft Function / blood
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Delayed Graft Function / etiology*
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Delayed Graft Function / urine
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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Immunosuppressive Agents / therapeutic use
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Interleukin-16 / blood*
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Interleukin-16 / urine
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Interleukin-2 Receptor alpha Subunit / blood*
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Kidney Diseases / blood
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Kidney Diseases / etiology*
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Kidney Diseases / urine
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Kidney Failure, Chronic / surgery*
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Kidney Transplantation / adverse effects*
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Logistic Models
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Male
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Middle Aged
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Predictive Value of Tests
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Prospective Studies
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Reperfusion Injury / blood
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Reperfusion Injury / etiology*
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Reperfusion Injury / urine
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Stem Cell Factor / blood*
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Stem Cell Factor / urine
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Time Factors
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Treatment Outcome
Substances
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Biomarkers
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IL2RA protein, human
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Immunosuppressive Agents
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Interleukin-16
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Interleukin-2 Receptor alpha Subunit
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Stem Cell Factor