Micro vs macro electrode DBS stimulation: A dosimetric study

Annu Int Conf IEEE Eng Med Biol Soc. 2010:2010:2057-60. doi: 10.1109/IEMBS.2010.5626487.

Abstract

Deep Brain Stimulation (DBS) is a clinically suitable technique for the treatment of the Parkinson's disease. Recently, also other neurological disorders such as Tourette syndrome, obsessive-compulsive disorder, epilepsy are being to be treated with DBS. However, the debate on its therapeutic mechanisms of action is still open. In order to a better understanding of such mechanisms, in this work the attention is focused on the DBS micro-stimulation. Indeed, a micro electrodes registration and stimulation is a fundamental step, during the surgical phase, to optimize the technique in terms of DBS lead positioning and DBS signal parameters. In this paper a dosimetric analysis with micro electrodes has been carried out, showing a more focused distribution of the electrical potential induced in the neuroanatomical tissues and changes of the excited/inhibited regions, respect to a macro electrodes stimulation.

MeSH terms

  • Biophysics / methods
  • Computer Simulation
  • Deep Brain Stimulation / instrumentation*
  • Deep Brain Stimulation / methods*
  • Electrodes*
  • Humans
  • Imaging, Three-Dimensional / methods
  • Magnetic Resonance Imaging / methods
  • Models, Theoretical
  • Obsessive-Compulsive Disorder / therapy
  • Parkinson Disease / therapy*
  • Radiometry / methods
  • Tourette Syndrome / therapy