Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer

Sebina Shrestha; Jesung Park; Paritosh Pande; Brian E Applegate; Javier A Jo

doi:10.1109/IEMBS.2010.5627569

Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer

Annu Int Conf IEEE Eng Med Biol Soc. 2010:2010:1970-3. doi: 10.1109/IEMBS.2010.5627569.

Authors

Sebina Shrestha¹, Jesung Park, Paritosh Pande, Brian E Applegate, Javier A Jo

Affiliation

¹ Department of Biomedical Engineering at Texas A&M University, College Station, TX, USA.

PMID: 21096785
DOI: 10.1109/IEMBS.2010.5627569

Abstract

Early detection of cancer is key to reducing morbidity and mortality. Morphological and chemical biomarkers presage the transition from normal to cancerous tissue. We have developed a noninvasive imaging system incorporating optical coherence tomography and fluorescence lifetime imaging to acquire both sets of biomarkers. Here we report early favorable results from an animal study designed to measure the capacity of this approach for early diagnosis of oral cancer.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Algorithms
Animals
Computer Simulation
Cricetinae
Dermoscopy / methods
Diagnostic Imaging / methods
Disease Models, Animal
Humans
Mesocricetus
Models, Statistical
Mouth Neoplasms / diagnosis*
Mouth Neoplasms / pathology*
Neoplasms, Glandular and Epithelial / diagnosis*
Neoplasms, Glandular and Epithelial / pathology*
Optics and Photonics / methods
Software
Tomography, Optical Coherence / methods

Grants and funding

1-R21-CA132433/CA/NCI NIH HHS/United States