Abstract
A relatively small cadre of lineage-restricted transcription factors largely orchestrates erythropoiesis, but how these nuclear factors interact to regulate this complex biology is still largely unknown. However, recent technological advances, such as chromatin immunoprecipitation (ChIP) paired with massively parallel sequencing (ChIP-seq), gene expression profiling, and comprehensive bioinformatic analyses, offer new insights into the intricacies of red cell molecular circuits.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / physiology
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Chromatin Immunoprecipitation
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Computational Biology
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Erythropoiesis*
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GATA1 Transcription Factor / physiology
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Gene Expression Profiling
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Humans
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Kruppel-Like Transcription Factors / physiology
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Proto-Oncogene Proteins / physiology
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T-Cell Acute Lymphocytic Leukemia Protein 1
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Transcription Factors / physiology*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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GATA1 Transcription Factor
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Kruppel-Like Transcription Factors
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Proto-Oncogene Proteins
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T-Cell Acute Lymphocytic Leukemia Protein 1
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Transcription Factors
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erythroid Kruppel-like factor
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TAL1 protein, human