Abstract
Previous genome-wide association studies have identified a strong association between FTO and human obesity, although the mechanism by which FTO affects obesity remains unknown. Anew study suggests that the obesity risk alleles are gain-of-function.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism
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Adiposity / drug effects
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Adiposity / genetics
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Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Animals
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Brain / metabolism
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Female
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Humans
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Male
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Mice
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Mixed Function Oxygenases
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Obesity / blood
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Obesity / genetics
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Oxo-Acid-Lyases / genetics
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Oxo-Acid-Lyases / metabolism*
Substances
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Adaptor Proteins, Signal Transducing
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Ftm protein, mouse
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Mixed Function Oxygenases
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FTO protein, mouse
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Alpha-Ketoglutarate-Dependent Dioxygenase FTO
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Oxo-Acid-Lyases