Abstract
Compared to the composite gold standard cytotoxin B assay and toxigenic culture, the loop-mediated isothermal amplification (LAMP) test for Clostridium difficile had a sensitivity and specificity of 98%, positive predictive value of 92%, and negative predictive value of >99%. A one-hour turnaround time for the LAMP test provides rapid diagnosis and cost savings.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacteriological Techniques / methods*
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Clostridioides difficile / genetics
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Clostridioides difficile / isolation & purification*
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DNA, Bacterial / genetics
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DNA, Bacterial / isolation & purification*
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Enterocolitis, Pseudomembranous / diagnosis*
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Enterocolitis, Pseudomembranous / microbiology
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Humans
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Nucleic Acid Amplification Techniques / methods*
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Predictive Value of Tests
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Sensitivity and Specificity
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Time Factors