Fat-induced inflammation unchecked

Olivia Osborn; Dorothy D Sears; Jerrold M Olefsky

doi:10.1016/j.cmet.2010.11.017

Fat-induced inflammation unchecked

Cell Metab. 2010 Dec 1;12(6):553-4. doi: 10.1016/j.cmet.2010.11.017.

Authors

Olivia Osborn¹, Dorothy D Sears, Jerrold M Olefsky

Affiliation

¹ Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 21109185
DOI: 10.1016/j.cmet.2010.11.017

Abstract

Increased dietary saturated fat intake can lead to detrimental effects on human health. In this issue of Cell Metabolism, Lichtenstein et al. (2010) show that by inhibiting lipoprotein lipase (LPL) activity in mesenteric lymph nodes, Angiopoietin-like protein 4 (Angptl4) protects resident macrophages from dietary saturated fatty acid (SFA)-induced inflammation.

Publication types

Comment

Abstract

Publication types

Grants and funding