What determines the specificity and outcomes of ubiquitin signaling?

Fumiyo Ikeda; Nicola Crosetto; Ivan Dikic

doi:10.1016/j.cell.2010.10.026

What determines the specificity and outcomes of ubiquitin signaling?

Cell. 2010 Nov 24;143(5):677-81. doi: 10.1016/j.cell.2010.10.026.

Authors

Fumiyo Ikeda¹, Nicola Crosetto, Ivan Dikic

Affiliation

¹ Frankfurt Institute for Molecular Life Sciences, Goethe University School of Medicine, Main, Germany.

PMID: 21111228
DOI: 10.1016/j.cell.2010.10.026

Abstract

Ubiquitin signals and ubiquitin-binding domains are implicated in almost every cellular process, but how is their functionality achieved in cells? We assess recent advances in monitoring the dynamics and specificity of ubiquitin networks in vivo and discuss challenges ahead.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Protein Interaction Domains and Motifs
Proteins / chemistry
Proteins / metabolism
Signal Transduction*
Ubiquitin / chemistry
Ubiquitin / metabolism*
Ubiquitination

Substances

Proteins
Ubiquitin