Impaired spatial working memory in children with well-controlled epilepsy: an event-related potentials study

Purpose: To find out whether children with epilepsy did show different event-related potentials (ERP) compared to healthy children during performance in a visuo-spatial working memory (WM) task.

Methods: Multichannel ERPs were measured during a visuo-spatial backmatching task. A quantitative analysis technique, based on Statistical Parametric Mapping, was used to analyze the ERP data. 62 children were tested (6-16 years old): 31 children with well-controlled epilepsy and 31 age- and intelligence-matched healthy children. One-backmatching (BM1) and two-backmatching (BM2) tasks were performed. Behavioral performance and target and nontarget ERPs were compared across groups in both tasks.

Results: No behavioral differences were found between groups in the easy BM1 task. In the difficult BM2 task, children with epilepsy made significantly more omission errors. ERP analysis showed significantly higher amplitudes over frontal and central regions between 300 and 500 ms poststimulus in the epilepsy group compared to the control group. This effect was most pronounced in BM2.

Discussion: This study shows that children with well-controlled epilepsy and normal intelligence demonstrate compensatory recruitment of their WM network during a visuo-spatial working memory task. Increasing the difficulty of the task (BM2) enhances this general neurophysiological finding and parallels the behavioral performance.

Significance: Our results illustrate that epilepsy induces different cortical activity during working memory tasks, even when behavioral performance is normal.