Spontaneous and in vitro induced apoptosis of lymphocytes and neutrophils in patients with alcohol dependence

S A Ivanova; N M Vyalova; E V Zhernova; N A Bokhan

doi:10.1007/s10517-010-0918-z

Spontaneous and in vitro induced apoptosis of lymphocytes and neutrophils in patients with alcohol dependence

Bull Exp Biol Med. 2010 Aug;149(2):246-9. doi: 10.1007/s10517-010-0918-z.

[Article in English, Russian]

Authors

S A Ivanova¹, N M Vyalova, E V Zhernova, N A Bokhan

Affiliation

¹ Laboratory of Cell and Biomolecular Studies, Institute of Mental Health, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.

PMID: 21113502
DOI: 10.1007/s10517-010-0918-z

Abstract

Spontaneous and induced apoptosis of neutrophils and lymphocytes was studied in alcoholics during the abstinent syndrome and in healthy individuals. In alcoholics, the levels of lymphocyte and neutrophil apoptosis at the receptor and cellular levels were higher than in healthy subjects. Blood cells from alcohol addicts and normal individuals similarly react to stimuli (hyperthermia and synthetic glucocorticoid prednisolone) in vitro.

MeSH terms

Adult
Alcoholism / immunology*
Alcoholism / pathology
Antibodies, Monoclonal
Apoptosis / physiology*
Fluorescent Antibody Technique, Indirect
Humans
Hyperthermia, Induced
In Vitro Techniques
Lymphocytes / pathology*
Lymphocytes / physiology
Middle Aged
Neutrophils / pathology*
Neutrophils / physiology
Prednisolone
Statistics, Nonparametric
fas Receptor / metabolism

Substances

Antibodies, Monoclonal
FAS protein, human
fas Receptor
Prednisolone