Emergence of VIM-1 metallo-β-lactamase-producing Escherichia coli in a neonatal intensive care unit

Microb Drug Resist. 2011 Mar;17(1):105-8. doi: 10.1089/mdr.2010.0097. Epub 2010 Nov 30.

Abstract

A carbapenem-resistant Escherichia coli isolate was recovered from rectal swab of a 12-day-old female neonate, which was admitted to a Greek neonatal intensive care unit (NICU). Phenotypic testing, polymerase chain reaction assays with sequencing, and plasmid analysis revealed that the isolate harbored a plasmid-mediated bla(VIM-1) metallo-β-lactamase gene. The appearance of a metallo-β-lactamase-producing E. coli in NICU is worrisome. Further surveys are needed to determine whether such Enterobacteriaceae may also be spreading in other NICUs.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Carbapenems / pharmacology
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / microbiology*
  • Female
  • Greece
  • Humans
  • Infant, Newborn
  • Intensive Care Units, Neonatal
  • Plasmids
  • Polymerase Chain Reaction
  • beta-Lactam Resistance
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • VIM-1 metallo-beta-lactamase
  • beta-Lactamases