Suicide attempt in ulcerative colitis patient after 4 months of infliximab therapy--a case report

E J Eshuis; K M M Y Magnin; P C F Stokkers; W A Bemelman; J Bartelsman

doi:10.1016/j.crohns.2010.04.001

Suicide attempt in ulcerative colitis patient after 4 months of infliximab therapy--a case report

J Crohns Colitis. 2010 Nov;4(5):591-3. doi: 10.1016/j.crohns.2010.04.001. Epub 2010 Jun 16.

Authors

E J Eshuis¹, K M M Y Magnin, P C F Stokkers, W A Bemelman, J Bartelsman

Affiliation

¹ Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

PMID: 21122565
DOI: 10.1016/j.crohns.2010.04.001

Abstract

In the summary of product characteristics of infliximab (IFX), psychiatric side effects are reported to be rare, and in literature only limited data exist. This report presents a case of a patient with ulcerative colitis who developed a depression with psychotic symptoms during IFX therapy and made a suicide attempt 4 months after the initiation of therapy. Although the time between start of IFX therapy and onset of symptoms could suggest a correlation, this, of course, does not prove that IFX was the causative factor for his depression and suicide attempt.

Publication types

Case Reports

MeSH terms

Adult
Anti-Inflammatory Agents / adverse effects*
Antibodies, Monoclonal / adverse effects*
Colitis, Ulcerative / drug therapy*
Colitis, Ulcerative / psychology*
Depressive Disorder / chemically induced*
Humans
Infliximab
Male
Suicide, Attempted*

Substances

Anti-Inflammatory Agents
Antibodies, Monoclonal
Infliximab