Abstract
Background:
This prospective observational study in typical community-based outpatient clinics evaluated the efficacy and toxicity of weekly and biweekly irinotecan-based chemotherapies and their compatibility depending on age.
Methods:
601 patients with advanced or metastatic colorectal cancer receiving first-, second-, or third-line irinotecan-based therapy were regularly analyzed for response and toxicity until the end of therapy.
Results:
The median age was 65 (28-87) years, approximately one-third of the patients were ≥70 years old. Of all patients, 405 were treated weekly and 68 biweekly. Median overall survival (OS) for first-line therapy was 26.5 months for the <70-year-old patients and 19.4 months for the ≥70-year-old patients. Toxicities were moderate in all groups. Tumor growth control rates (TCR) and median time to progression (TTP) were marginally better for patients <70 years old. Median TTP was 9.9 months in first-line therapy, 9.8 months after adjuvant therapy, 7.7 months in second-line, and 6.4 months in third-line therapy.
Conclusions:
Toxicity and response data from this observational study clearly confirm the positive results from previous clinical studies and show a slight ad-vantage in efficacy for the <70-year-old patients.
Copyright © 2010 S. Karger AG, Basel.
Publication types
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Clinical Trial, Phase IV
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Multicenter Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / mortality
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Adenocarcinoma / pathology
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Adenocarcinoma / surgery
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Adult
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Age Factors
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Aged
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Antineoplastic Combined Chemotherapy Protocols / toxicity
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Camptothecin / administration & dosage
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Camptothecin / analogs & derivatives*
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Camptothecin / toxicity
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Chemotherapy, Adjuvant
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Clinical Trials as Topic
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Colorectal Neoplasms / drug therapy*
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Colorectal Neoplasms / mortality
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Colorectal Neoplasms / pathology
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Colorectal Neoplasms / surgery
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Combined Modality Therapy
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Disease Progression
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Drug Administration Schedule
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Drug-Related Side Effects and Adverse Reactions
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / toxicity
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Humans
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Irinotecan
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Leucovorin / administration & dosage
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Leucovorin / toxicity
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Male
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Middle Aged
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Neoplasm Staging
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / toxicity
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Prospective Studies
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Survival Rate
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Treatment Outcome
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Tumor Burden
Substances
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Organoplatinum Compounds
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Irinotecan
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Leucovorin
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Fluorouracil
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Camptothecin