Low-dose, low-concentration levobupivacaine plus fentanyl selective spinal anesthesia for knee arthroscopy: a dose finding study

Anesth Analg. 2011 Feb;112(2):477-80. doi: 10.1213/ANE.0b013e318202cd03. Epub 2010 Dec 2.

Abstract

Background: Selective sensory spinal anesthesia preserves lower limb motor function and thus facilitates postanesthesia care unit (PACU) bypass and reduces ambulation recovery time.

Methods: We compared the ambulation time and PACU bypass rate after using 3 low-dose, low-concentration levobupivacaine-fentanyl spinal solutions (5, 4, and 3 mg + 10 μg) in a double-blind study consisting of 90 patients (ASA physical status I and II) scheduled to undergo knee arthroscopy.

Results: The 3-mg dose was halted because of a large number of inadequate blocks (50%). Twenty-three percent and 80% of patients from groups 5 mg and 4 mg, respectively, bypassed the PACU (P = 0001). Ambulation took place after 70 minutes (30-130 minutes) (median [range]) in group 5 mg and 45 minutes (23-120 minutes) in group 4 mg (P = 0006).

Conclusion: Four milligrams levobupivacaine plus 10 μg fentanyl produced adequate surgical anesthesia with the shortest time to ambulation and the highest PACU bypass rate.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analgesics, Opioid / administration & dosage*
  • Anesthesia Recovery Period
  • Anesthesia, Spinal*
  • Anesthetics, Local / administration & dosage*
  • Arthroscopy*
  • Bupivacaine / administration & dosage
  • Bupivacaine / analogs & derivatives
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Early Ambulation
  • Female
  • Fentanyl / administration & dosage*
  • Humans
  • Knee / surgery*
  • Levobupivacaine
  • Male
  • Middle Aged
  • Motor Activity / drug effects
  • Patient Discharge
  • Prospective Studies
  • Sensation / drug effects
  • Spain
  • Time Factors

Substances

  • Analgesics, Opioid
  • Anesthetics, Local
  • Levobupivacaine
  • Fentanyl
  • Bupivacaine